Thomas Margolis, M.D.

T Margolis 2022

Thomas I. Margolis, M.D.

Retina Specialist

Office Address:

1500 Tilton Rd.,
Northfield, NJ 08225
Phone: 609.646.5200
Fax: 609.646.9868

Professional Experience

RETINAL AND OPHTHALMIC CONSULTANTS, PC, Northfield, NJ,
1995 - Present. Private group practice limited to vitreoretinal diseases and surgery. Participation in clinical trials.

Education:

HARVARD MEDICAL SCHOOL, Boston, MA, 1984-1989. MD, Magna Cum Laude. Honors thesis: "New Mid-Infrared Lasers for Vitreous Membrane Cutting and Sclerostomy".

UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA, 1980-84. BA in Economics and Chemistry (with honors). Summa Cum Laude.

UNIONTOWN AREA SENIOR HIGH SCHOOL, Uniontown, PA. Valedictorian, 1980.

Postgraduate Training:

NEW ENGLAND EYE CENTER, TUFTS UNIVERSITY SCHOOL OF MEDICINE, Boston, MA,
1993-1995. Vitreoretinal fellowship.

WILLS EYE HOSPITAL, THOMAS JEFFERSON UNIVERSITY SCHOOL OF MEDICINE, Philadelphia, PA,
1990-1993. Ophthalmology residency.

CEDARS-SINAI MEDICAL CENTER, UCLA SCHOOL OF MEDICINE, Los Angeles, CA,
1989-90. Internal medicine internship.

MASSACHUSETTS EYE AND EAR INFIRMARY, HARVARD MEDICAL SCHOOL, Boston, MA.
Laser research fellowship. 1987-1988.

Academic Appointment:

TUFTS UNIVERSITY SCHOOL OF MEDICINE: Instructor-in-Ophthalmology,
1993-1995.

Hospital Appointments:

SHORE MEDICAL CENTER (SHORE MEMORIAL HOSPITAL), Somers Point, NJ: Chief of Ophthalmology January  2022 to Present.

Attending Ophthalmologist, 1995-2021.

ATLANTICARE REGIONAL MEDICAL CENTER, Atlantic City, NJ: Attending Ophthalmologist, 1995-present.

BETTY BACHARACH REHABILITATION HOSPITAL, Pomona, NJ: Consulting Ophthalmologist, 1995-2010.

NEW ENGLAND MEDICAL CENTER, Boston, MA: Assistant-in-Ophthalmology, 1993-1995.

MASSACHUSETTS EYE AND EAR INFIRMARY, Boston, MA: Assistant-in-Ophthalmology, 1994-1995.

BOSTON VETERANS ADMINISTRATION MEDICAL CENTER, Boston, MA: Attending Ophthalmologist, 1993-1995.

Certification And Licensure:

  • New Jersey 1991-present
  • Pennsylvania 1991-present
  • Massachusetts Inactive
  • American Board of Ophthalmology, Diplomat 1995; Recertified 2005, 2015
  • National Board of Medical Examiners, Diplomat 1990
  • Certified examiner for STOP-ROP Study (Supplemental Therapeutic Oxygen for
    Pre-Threshold Retinopathy of Prematurity) 1993-1995

Awards And Honors:

  • Philadelphia Magazine's TopDocs TM 2004-2022
  • Inside Jersey Top Doctors 2010 – 2017
  • New Jersey Magazine Top Doctors 2018 - 2020
  • Marquis Who's Who Albert Nelson Marquis Lifetime Achievement Award 2021
  • Marquis Who's Who in the World®, 2015-2016
  • Marquis Who’s Who in America, 2005-2016
  • Marquis Who’s Who in the East, 1997-1998, 2005-2016
  • Marquis Who’s Who in in Medicine and Healthcare, 2004-2007, 2009-2012
  • Marquis Who's Who in Science and Engineering, 2011-2012, 2016-2017
  • Suburban Life Top Doctors 2016
  • US News and World Report, “Top Doctors” 2012 and 2013
  • New Jersey Monthly, “The Best Doctors in New Jersey” Sept. 2003 & Sept. 2005
  • New Jersey Life Magazine, “Top Docs” March 2005
  • “America’s Top Ophthalmologists”, Consumer’s Research Council of America, 2004 - 2014
  • Strathmore’s Who’s Who, 2005-2006
  • National Register’s WHO’S WHO IN EXECUTIVES & PROFESSIONALS, 2004 -2006
  • Laurence B. Ellis Scholar-Harvard Medical School-1987-88
  • Soma Weiss Assembly-Harvard Medical School-1986, 1989
  • Merck Senior Chemistry Award-University of Pennsylvania-1984
  • Phi Beta Kappa-1983
  • Benjamin Franklin Scholar-University of Pennsylvania-1980-84
  • Alpha Epsilon Delta Pre-Medical Honor Society-1983

Major Memberships/committee:

  • Atlantic County Medical Society 1995 – present
  • President 2007-8; Executive Committee, 2003 - present
  • Medical Society of New Jersey, Credentials Committee, 2001 - present
  • New Jersey Medical Board, Expert Reviewer, 1995 - present
  • American Society of Retina Specialists 1996 - present
  • Retina Society of New Jersey 1995 - present
  • New Jersey Academy of Ophthalmology 1995 - present
  • Medical Society of New Jersey 1995 - present
  • Wills Eye Hospital Society 1993 - present
  • American Academy of Ophthalmology 1990 - present
  • American Medical Association 1989 - present
  • Association for Research in Vision and Ophthalmology 1988 - 2002
  • University of Pennsylvania Career Network Advisor 1995 – present

Research Experience:

RHONE-X GR41987 – Sub-Investigator

F. Hoffmann-La Roche Ltd
December 2020 – Present
A Multicenter, Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of Faricimab (RO6867461) in Patients with Diabetic Macular Edema.

AMGEN 20170542 – Principal Investigator

Amgen Inc. and Parexel International LLC
February 2020 – Present
A Randomized, Double-masked, Phase 3 Study of ABP938 Efficacy and Safety
Compared to Aflibercept (Eylea) in Subjects with Neovascular Age-related Macular Degeneration.

PANDA KHB-1802 – Sub-Investigator

Syneos Health, LLC
October 2019 – Present
A Multicenter, Double-Masked, Randomized, Dose-Ranging Trial to Evaluate the Efficacy and Safety of Conbercept Intravitreal Injection in Subjects with Neovascuular Age-related Macular Degeneration.

SAGA ALK001-P3001 – Sub-Investigator

Alkeus Pharmaceuticals, Inc.
October 2019 – Present
A Phase 2/3 Multicenter, Randomized, Double–Masked, Parallel–Group, Placebo–Controlled Study to Investigate the Safety, Pharmacokinetics, Tolerability, and Efficacy of ALK-001 in Geographic Atrophy Secondary to Age–related Macular Dengeneration.

YOSEMITE GR40349 – Sub-Investigator

F. Hoffmann-La Roche Ltd
July 2018 – Present
Phase III, Multicenter, Randomized, Double-Masked, Active Comparator–Controlled Study to Evaluate the Efficacy and Safety of RO6867461 in Patients with Diabetic Macular Edema.

AERPIO AKB-9778-CI-5001 – Sub-Investigator

Aerpio Therapeutics LLC
August 2017 – May 2018
Phase 2 Double-Masked, Placebo-Controlled Study to Assess the Safety and Efficacy of Subcutaneously Administered AKB-9778 15MG Once Daily or 15MG Twice Daily for 12 Months in Patients with Moderate to Severe Non-Proliferative Diabetic Retinopathy.

OMASPECT GX30191 – Sub-Investigator

F. Hoffman-La Roche Ltd
March 2017 – April 2018
A Multicenter, Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of Lampalizumab in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration Who Have Completed a Roche-Sponsored Study.

TOGA-01 Phase II/III – Sub-Investigator

University of Virginia Department of Ophthalmology
February 2017 – December 2019
A Randomized, Double Masked, Placebo-Controlled Study Evaluating ORACEA® in Subjects with Geographic Atrophy Secondary to Non-Exudative Age-Related Macular Degeneration

MAKO-OHR-1601 / Chiltern Study Code No. 35544 – Principal Investigator

OHR Pharmaceutical, Inc.
June 2016 – July 2017
Phase III Study of the Efficacy and Safety of Squalamine Lactate Ophthalmic Solution, 0.2% Twice Daily in Subjects with Neovascular Age-Related Macular Degeneration.

?PROTOCOL. W – Sub-Investigator

DRCR.net
May 2016 – July 2018
Intravitreous Anti-VEGF Treatment for Prevention of Vision Threatening Diabetic Retinopathy in Eyes at High Risk

CAPELLA R2176-3-AMD-1417 – Principal Investigator

Regeneron
September 2015 – September 2016
A Phase 2, Double-Masked, Randomized, Controlled, Multiple-Dose, Regimen-Ranging Study of the Efficacy and Safety of Intravitreal REGN2176-3 in Patients with Neovascular Age-Related Macular Degeneration.

SPECTRI GX29185 – Sub-Investigator

F. Hoffman-La Roche Ltd
August 2014 – April 2018
A Phase III, Multicenter, Randomized, Double-Masked, Sham-Controlled Study to Assess the Efficacy and Safety of Lampalizumab Administered Intravitreally to Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration.

SCORE2 – Principal Investigator

National Eye Institute, National Institutes of Health, Department of Health and Human Services
March 2014 - 2015
Study of Comparative Treatments for Retinal Vein Occlusion 2 (SCORE2): A Multicenter, Prospective, Randomized, Phase III Non-Inferiority Trial of Eyes with Macular Edema Secondary to Central Retinal Vein Occlusion, Comparing Intravitreal Bevacizumab Every 4 Weeks Versus Intravitreal Aflibercept Every 4 Weeks.

ORBIT TG-MV-018 – Principal Investigator

ThromboGenics, Inc.
February 2014 - 2015
A Multicenter, Prospective, Observational Phase 4 Study That Will Assess Clinical Outcomes and Safety of Jetrea Administered in a Real-World Setting for the Treatment of Symptomatic Vitreomacular Adhesion (VMA) by Assessing Anatomical and Functional Outcomes in 1500 Patients Recruited Across Approximately 120 USA Retina Sites.

ECLIPSE OPH1002A – Sub-Investigator

Ophthotech Corp
September 2013 – August 2016
A Phase III Randomized, Double-Masked, Controlled Trial to Establish the Safety and Efficacy of Intravitreous Administration of Fovista (Anti PDGF-B Pegylated Aptamer) Administered in Combination with Lucentis Compared to Lucentis Monotherapy in Subjects with Subfoveal Neovascular Age-Related Macular Degeneration.

BAM 114341 – Sub-Investigator

Glaxo Smith Kline
March 2013 - 2015
A phase II Multicenter, Randomized, Double-Masked, Placebo-Controlled, Parallel-Group Study to Investigate the Safety, Tolerability, Efficacy, Pharmacokinetics and Pharmacodynamics of GSK933776 in Adult Patients with Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD).

VGFTe-AMD-1124 – Principal Investigator

Regeneron
January 2013 - 2014
An Open-Label Study of the Efficacy, Safety and Tolerability of Intravitreal Administration of VEGF Trap-Eye (Intravitreal Aflibercept Injection) in Patients with Neovascular Age-Related Macular Degeneration.

PROTOCOL. S – Sub-Investigator

DRCR.net
July 2012 – April 2018
Prompt Panretinal Photocoagulation versus Ranibizumab and Deferred Panretinal Photocoagulation for Proliferative Diabetic Retinopathy Studies.

PROTOCOL. V – Sub-Investigator

DRCR.net
July 2012 – July 2018
Treatment for Central-Involved Diabetic Macular Edema in Eyes with Very Good Visual Acuity

VIBRANT – Principal Investigator

Regeneron
June 2012 - 2013
Protocol: VGFT e-RVO-1027
A Double-Masked, Randomized, Active-Controlled Study of the Efficacy, Safety and Tolerability of Intravitreal Administration of VEGF Trap-Eye (intravitreal aflibercept injection(IAI) in patients with macular edema secondary to branch retinal vein occlusion).

SAKURA – Sub-Investigator

Santen Incorporated
2011 - 2013
Protocol No. 32-007P
Phase III, Multinational, Multi-Center, Randomized, Double-Masked Study Assessing the Safety and Efficacy of Intravitreal Injections of DE-109 (three doses) for the Treatment of Active, Non-Infectious Uveitis of the Posterior Segment of the Eye

VISTA – Principal Investigator

Regeneron
2011 - 2013
Protocol: VGFT-OD-1009
A Double-Masked, Randomized, Active-Controlled, Phase3. A Study of the Efficacy and Safety of Intravitreal Administration of VEGF Trap-Eye in Patients with Diabetic Macular Edema. PAREXEL # 201601

SHORE – Sub-Investigator

Genentech
2011 - 2013
BB-IND 8633 – Protocol FVF4967g
A Multi-center Randomized Study Evaluating Dosing Regimens For Treatment with Intravitreal Ranibizumab Injections in Subjects with Macular Edema Following Retinal Vein Occlusion.

VIEW 1 Extension – Principal Investigator

Regeneron
2010 - 2012
Protocol: VGFT-OD-0910
Open-Label, Long-Term, Safety and Tolerability Extension Study of Intravitreal VEGF Trap-Eye in Neovascular Age-Related Macular Degeneration.

NAION – Sub-Investigator

Regeneron
2010 - 2012
Protocol: VGFT-OD-0910
Open-Label, Long-Term, Safety and Tolerability Extension Study of Intravitreal VEGF Trap-Eye in Neovascular Age-Related Macular Degeneration.

COPERNICUS – Principal-Investigator

Regeneron
2009 - April 2012
Protocol: VGFT-OD-0819
Randomized, Double-Masked, Controlled Phase III Study of the Efficacy, Safety and Tolerability of Repeated Administration of VEGF Trap-Eye in Subjects with Macular Edema Secondary to Central Retinal Vein Occlusion (CRVO).

HARBOR – Sub-Investigator

Genentech
2009 - 2012
Protocol: FVF4579G
Phase III, Double-Masked, Multi-Center, Randomized, Active Treatment, Controlled Study of the Efficacy and Safety of 0.5 mg and 2.0 mg Ranibizumab; Administered Monthly or on an As-Needed Basis (PRN) in Patients with Subfoveal Neovascular Age-Related Macular Degeneration.

RISE – Sub-Investigator

Genentech
2008 - 2012
Protocol: FVF4170G
Three-Year Multi-Center Study with Monthly Visits for Patients with Diabetic Macular Edema Comparing Lucentis with Standard of Care Laser Treatments.

CRUISE – Sub-Investigator

Genentech
2008 - 2010
Protocol: FVF41669
One Year Multi-Center Study with Monthly Visits Comparing Lucentis to Sham Procedure for Patients with Central Retinal Vein Occlusion.

DAVINCI – Principal Investigator

Regeneron
2008 - 2010
Protocol: VGFT-OD-0706
A Double-Masked, Randomized, Controlled Study of the Safety, Tolerability and Biological Effect of Repeated Intravitreal Administration of VEGF Trap-Eye in Patients with Diabetic Macular Edema (DME).

HORIZON – Sub-Investigator

Genentech
2008 - 2010
Protocol: FVF3426G
Open-Label, Multi-Center Extension Study to Evaluate the Safety and Tolerability of Ranibizumab in Subjects with Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD) or Macular Edema Secondary to Retinal Vein Occlusion (RVO) who have Completed a Genentech-Sponsored Ranizumab Study.

VIEW1 – Principal Investigator

Regeneron
2007 - 2010
Protocol: VGFT-OD-0605
Two Year Multi-Center Study with Monthly Visits Comparing VEGF-Trap Against Lucentis for Patients with Newly-Diagnosed, Age-Related Macular Degeneration.

SIRIUS – Principal Investigator

Allergan
2006 - 2008
Protocol: 211745-001-01
Two Year Multi-Center Study Comparing Sirna Against Lucentis for Age-Related Macular Degeneration

NOTAL VISION HMP-V4 – Sub-Investigator

Notal Vision
2006 - 2007
Protocol: 20071801
Sensitivity of the Home Macular Perimeter (HMP) in Detection of Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (ARMD)

SAILOR – Sub-Investigator

Genentech, Inc.
2003 - 2007
Protocol: FVF3689G
One Year Multi-Center Study to Evaluate the Safety and Tolerability of Lucentis in Newly-Diagnosed and Previously Treated Subjects with Age-Related Macular Degeneration.

RhuFab V2 (ranibizumab) – Principal Investigator

Genentech, Inc.
2003 - 2005
Protocol FVF2587g
A Phase III Multicenter, Randomized, Double-Masked, Active Treatment-Controlled Study of the Efficacy and Safety of RhuFab V2 (ranibizumab) Compared with verteporfin (Visudyne) Photodynamic Therapy in Subjects with Predominantly Classic Subfoveal Neovascular Age-Related Macular Degeneration.

Verteporfin Photodynamic Therapy – Principal Investigator

Ciba Vision
1999 - 2000
Protocol BPD OCR 005
An Open-Label, Multicenter, Safety Study of the Treatment of Predominantly Classic Subfoveal Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD) Using Photodynamic Therapy with Verteporfin for Injection.

Flibanserin

University of Pennsylvania and Boehringer Ingelheim (BI Trial No. 511.11)
1997 - 1998
An Eight-Week, Double-Blind, Placebo-Controlled Phase II Study of Various Doses of Flibanserin and Paroxetine in Patients with Major Depressive Disorder. Our Role was to Perform Ophthalmic Examinations to Evaluate for Potential Ocular Complications and Side Effects.

Pioglitazone

Takeda America, Inc.
1996
A Double-Blind Placebo-Controlled, Randomized, Dose-Titration Study to Evaluate the Safety and Efficacy of Pioglitazone, an Oral Hypoglycemic Agent. Our role was to perform retinal examinations and evaluate retinal photographs for evidence of diabetic retinopathy.

Adefovir Dipivoxil (bis-POM PMEA)

NJCRI
1996 - 1997
A Placebo-Controlled Study of the Safety and Efficacy of Adefovir Dipovoxil (bis-POM PMEA) in Prolonged Survival of HIV-Infected Individuals with a CD4+ Cell Count of 100/mm3. Our role was for ophthalmic evaluation with emphasis on the presence or absence of CMV retinitis.

WILMER EYE INSTITUTE, JOHNS HOPKINS UNIVERSITY. Acted as field supervisor in Liberia for a large scale clinical trial of ivermectin in the treatment of onchocerciasis. 1988.

BRIGHAM AND WOMEN'S HOSPITAL, Boston, MA. Biomedical research on the effects of acidosis on cultured ventricular cells, 1985.

Bibliography:

Articles

Duker, JS, Margolis TI: How to treat BRVO. Rev Ophthalmol 1995; 2 (12):50-51.

Avvad FK, Duker JS, Reichel E, Margolis TI, Puliafito CA: The digital indocyanine green videoangiography characteristics of well-defined choroidal neovascularization. Ophthalmol 1995; 102:401-405.

Margolis TI, Duker JS: Review of "Atlas of Intraocular Tumors". Am J Ophthalmol 1994; 118:688.

Margolis TI, Duker JS: Laser treatment of retinal vein occlusion. Ophthalmic Practice 1994; 12 (1):8-12,42.

Borirakchanyavat S, Puliafito CA, Kliman GH, Margolis TI, Galler E: Holmium-YAG laser surgery on experimental vitreous membranes. Arch Ophthalmol 1991; 109:1605-1609.

Margolis TI, Farnath DA, Destro M, Puliafito CA: Erbium-YAG laser surgery on experimental vitreous membranes. Arch Ophthalmol 1989; 107:424-428.

Marsh JD, Margolis TI, Kim D: Mechanism of diminished contractile response to catecholamines during acidosis. Am J Physiol 1988; 254:H20-27.

Chapters

Margolis TI: Contributor to ten sections in Retina and Uveitis chapters. In: Cullum RD and Chang B, ed., The Wills Eye Manual-Office and Emergency Room Diagnosis and Treatment of Eye Disease. Second Edition. J. B. Lippincott Co., Philadelphia, 1994.

Abstracts

Margolis TI, Duker JS, Reichel E, Rutledge BK, Morley MG, Davis JL: Repair of retinal detachments related to cytomegalovirus retinitis in eyes with ganciclovir implants. Invest Ophthalmol Vis Sci 1995; 36(4):S778.

Jivanjee SQ, Duker JS, Margolis TI, Reichel E, Puliafito CA, Morley MG: Pneumatic buckle: an alternative technique for the treatment of retinal detachment without subretinal fluid drainage. Invest Ophthalmol Vis Sci 1995; 36(4):S850.

Rutledge BK, Morley MG, Duker JS, Margolis TI: Combination antiviral therapy for the progressive outer retinal necrosis syndrome. Invest Ophthalmol Vis Sci 1995; 36(4):S318.

Margolis TI, Duker JS, Reichel E, Puliafito CA: Indirect diode laser photocoagulation for threshold and posterior prethreshold retinopathy of prematurity. Invest Ophthalmol Vis Sci 1994; 35(4):1443.

Margolis TI, Farnath DA, Puliafito CA: Mid-infrared laser sclerostomy. Invest Ophthalmol Vis Sci

1988; 29 (supp):366.

Farnath, DA, Margolis TI, Destro M, Puliafito CA: Erbium-YAG laser surgery on experimental vitreous membranes in rabbits. Invest Ophthalmol Vis Sci 1988; 29 (supp):292.

Borirak S, Margolis TI, Kliman GH, Puliafito CA: Holmium-YAG laser surgery on experimental vitreous membranes in rabbits. Invest Ophthalmol Vis Sci 1989; 30 (supp):372.

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